Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease
Identifieur interne : 000178 ( Main/Exploration ); précédent : 000177; suivant : 000179Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease
Auteurs : Samay Jain [États-Unis] ; Greg J. Siegle [États-Unis] ; Chen Gu [États-Unis] ; Charity G. Moore [États-Unis] ; Larry S. Ivanco [États-Unis] ; Stephanie Studenski [États-Unis] ; J. Timothy Greenamyre [États-Unis] ; Stuart R. Steinhauer [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-06.
English descriptors
Abstract
Background:: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease. Methods:: Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome. Results:: Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale–sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest. Conclusions:: Pupillary unrest correlates with motor and nonmotor features associated with Lewy‐related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23628
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Moore</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ivanco, Larry S" sort="Ivanco, Larry S" uniqKey="Ivanco L" first="Larry S." last="Ivanco">Larry S. 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Timothy Greenamyre</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Steinhauer, Stuart R" sort="Steinhauer, Stuart R" uniqKey="Steinhauer S" first="Stuart R." last="Steinhauer">Stuart R. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-06">2011-06</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1344">1344</biblScope><biblScope unit="page" to="1347">1347</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5AA9951AA8E86A465C49FD0B71D64B73B874131E</idno><idno type="DOI">10.1002/mds.23628</idno><idno type="ArticleID">MDS23628</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>autonomic dysfunction</term><term>nonmotor features</term><term>pupil</term><term>sleep disorders</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease. Methods:: Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome. Results:: Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale–sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest. Conclusions:: Pupillary unrest correlates with motor and nonmotor features associated with Lewy‐related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Jain, Samay" sort="Jain, Samay" uniqKey="Jain S" first="Samay" last="Jain">Samay Jain</name></region><name sortKey="Greenamyre, J Timothy" sort="Greenamyre, J Timothy" uniqKey="Greenamyre J" first="J. Timothy" last="Greenamyre">J. Timothy Greenamyre</name><name sortKey="Greenamyre, J Timothy" sort="Greenamyre, J Timothy" uniqKey="Greenamyre J" first="J. Timothy" last="Greenamyre">J. Timothy Greenamyre</name><name sortKey="Greenamyre, J Timothy" sort="Greenamyre, J Timothy" uniqKey="Greenamyre J" first="J. Timothy" last="Greenamyre">J. Timothy Greenamyre</name><name sortKey="Gu, Chen" sort="Gu, Chen" uniqKey="Gu C" first="Chen" last="Gu">Chen Gu</name><name sortKey="Ivanco, Larry S" sort="Ivanco, Larry S" uniqKey="Ivanco L" first="Larry S." last="Ivanco">Larry S. Ivanco</name><name sortKey="Jain, Samay" sort="Jain, Samay" uniqKey="Jain S" first="Samay" last="Jain">Samay Jain</name><name sortKey="Moore, Charity G" sort="Moore, Charity G" uniqKey="Moore C" first="Charity G." last="Moore">Charity G. Moore</name><name sortKey="Siegle, Greg J" sort="Siegle, Greg J" uniqKey="Siegle G" first="Greg J." last="Siegle">Greg J. Siegle</name><name sortKey="Steinhauer, Stuart R" sort="Steinhauer, Stuart R" uniqKey="Steinhauer S" first="Stuart R." last="Steinhauer">Stuart R. Steinhauer</name><name sortKey="Steinhauer, Stuart R" sort="Steinhauer, Stuart R" uniqKey="Steinhauer S" first="Stuart R." last="Steinhauer">Stuart R. Steinhauer</name><name sortKey="Studenski, Stephanie" sort="Studenski, Stephanie" uniqKey="Studenski S" first="Stephanie" last="Studenski">Stephanie Studenski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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